If you're counting opt-outs, I think there's several teams in that boat right now, and that's while ignoring the Cardinals and Marlins. The Astros are missing Verlander, Urquidy, and almost their whole bullpen. The Mets are missing Wacha, Syndegaard, Stroman just opted out, and Degrom has a finger issue, Cano, Lowrie, Nunez, Marisnick, and an opt-out by Cespedes. We play this game every year, this year we just also have 2 teams that lost 50% of their players at once.