I think it's easier to win without premium position players than it is without premium starting pitching. With all the injuries last year, the Sox had significant playing time from Garcia, Goodwin, Mercedes, Collins, Hernandez, Mendick, Sheets, Hamilton, Zavala and Lamb and still won the division easily.
If Giolito or Lynn are down for longer than expected or Cease/Kopech have injuries, it will be much harder to overcome.