I'd say the big thing is how bad does Colon want to stay here. I think the Sox have made an offer that will secure Colon's future for the rest of his life. He knows after signing this contract he will be set.
Now he has to decide whether its alright with him to sign for a little less to stay in a place he likes (If he really likes it here) and to have a home for a while.
BottomLine: I think we will have the front four back next season. I also think we'll see Buehrle signed long term (Now is a good time to do it, imo).
Sox will move Konerko, imo...and I think you may not see Roberto or Jose back. They may stick with Harris/Miles at 2nd and sign a vet (You know that a vet middle infielder will be out there late in free agency available for absolutely nothing). Then at short I think the Sox may just invest some money or go get a young talented shortstop (Possibly Christian Guzman if available...maybe a David Eckstein..I hope no Eckstein).
Will have some more ideas once free agency starts and you see who exactly is out there. If Guzman is there I'd sign him in a heartbeat. But in that case you'd need to find a leadoff hitter.